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Quaternary Pump, Autosampler, Detector, Column Compartment, Control Module
pL/min to 10 mL/min (flowrate)
approx. 40 x 50 x 60 cm (each module varies)
Agilent 1260 Infinity III, Agilent 1260 HPLC, Agilent 1260 Infinity 3, Agilent 1260 Price
The 1260 Infinity III LC System is a robust analytical high-performance liquid chromatography (HPLC) system that offers the widest choice of modules for analytical HPLC and entry-level UHPLC analysis. This HPLC instrument delivers the performance, reliability, and robustness you need for highest confidence in your daily HPLC results.
1. Advanced Modular Design
The 1260 Infinity III HPLC system features a sophisticated modular architecture, allowing users to configure modules-pumps, detectors, autosamplers, and column compartments-to specific workflow requirements. The system offers fast data acquisition and enhanced robustness, supporting rapid throughput and consistent performance in diverse laboratory environments.
2. Multiple Gradient and Detection Modes
Whether you need binary, quaternary, or isocratic gradients, the system efficiently handles complex separations. Detection options such as diode array detector (DAD), variable wavelength, fluorescence, refractive index, and mass spectrometry compatibility deliver analytical versatility for a wide range of sample types and research applications.
3. Enhanced Compliance and Connectivity
Designed for stringent regulatory environments, the 1260 Infinity III meets global GLP, cGMP, and 21 CFR Part 11 standards. Coupled with OpenLAB CDS, ChemStation, or MassHunter control software and multi-port data interfaces (LAN, USB, RS232), the platform ensures secure data handling, traceability, and seamless integration into laboratory information systems.
Type | High-Performance Liquid Chromatography (HPLC) System |
Capacity | Max pressure up to 600 bar |
| Weight | approx. 35 - 55 kg (depends on module configuration) |
| Feature | Modular system, fast data acquisition, high robustness, advanced diagnostics |
| Equipment Materials | Metal and chemical-resistant polymers |
| Temperature Range | 4C to 80C for column compartments |
| Automation Grade | Automatic / Programmable |
| Display Type | Color graphical LCD touchscreen |
| Core Components | Quaternary Pump, Autosampler, Detector, Column Compartment, Control Module |
| Measurement Range | pL/min to 10 mL/min (flowrate) |
Dimension (L*W*H) | approx. 40 x 50 x 60 cm (each module varies) |
| Usage | Analytical, pharmaceutical, life sciences, research laboratories |
| Accuracy | Flow accuracy 1% |
| Detection Options | Diode Array Detector (DAD), Variable Wavelength, Fluorescence, RID, MS-ready |
Pump Configuration | Dual or quaternary gradient |
| Gradient Capability | Binary, quaternary, isocratic options |
| Sample Capacity | Up to 132 vials (with multi-drawer autosampler) |
| Compliance | GLP, cGMP, 21 CFR Part 11 |
| Injection Volume Range | 0.1 L to 100 L |
| Analytical Flow Range | 0.0110 mL/min |
Noise Level | <0.001 AU |
| Data Interface | LAN, USB, and RS232 ports |
| Control Software | OpenLAB CDS, ChemStation, MassHunter |
FAQ's of Agilent Technologies 1260 Infinity III LC System:
Q: How do I choose between binary, quaternary, or isocratic operation for my analysis on the 1260 Infinity III LC System?
A: Select binary or quaternary gradient modes if your method requires mixing two or more solvents for enhanced separation efficiency; use isocratic operation for simpler analyses involving a constant mobile phase. The modular pump configuration allows rapid adaptation to each chromatographic need.
Q: What is the process for injecting samples, and what is the supported injection volume range?
A: Samples are loaded into the autosampler, which accommodates up to 132 vials with the multi-drawer option. The system supports programmable injection volumes from 0.1 L to 100 L, ensuring accuracy and versatility for different sample concentrations and method requirements.
Q: When should I consider using specific detectors such as DAD, VWD, fluorescence, RID, or MS with this system?
A: Choose DAD or VWD for UV-visible absorbing compounds, fluorescence for highly sensitive detection of fluorescent analytes, RID for carbohydrates or non-UV absorbing substances, and the MS-ready configuration when mass spectrometric identification or quantitation is necessary.
Q: Where is the Agilent 1260 Infinity III LC System commonly used?
A: This system is widely adopted in analytical, pharmaceutical, life sciences, and research laboratories across academic, industrial, and regulatory settings-especially where high throughput, precision, and regulatory compliance are critical.
Q: What are the main benefits of using the 1260 Infinity III LC System in regulated environments?
A: The system's compliance with GLP, cGMP, and 21 CFR Part 11 ensures traceability, secure data management, and support for audits. Advanced diagnostics, automation features, and robust hardware contribute to minimized downtime and highly reproducible results.
Q: How does the system ensure method flexibility and reliability in analytical workflows?
A: The modular design, broad flow rate (pL/min to 10 mL/min), wide temperature control (4C to 80C), and interchangeable detection modules allow rapid adaptation and optimization for diverse samples and protocols, ensuring reliable results regardless of analysis complexity.
